Article
Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population.
Genes and immunity - 1 Jul 2009
Guo L, Deshmukh H, Lu R, Vidal G S, Kelly J A, Kaufman K M, Dominguez N, Klein W, Kim-Howard X, Bruner G R, Scofield R H, Moser K L, Gaffney P M, Dozmorov I M, Gilkeson G S, Wakeland E K, Li Q-Z, Langefeld C D, Marion M C, Williams A H, Divers J, Alarcón G S, Brown E E, Kimberly R P, Edberg J C, Ramsey-Goldman R, Reveille J D, McGwin G, Vilá L M, Petri M A, Vyse T J, Merrill J T, James J A, Nath S K, Harley J B, Guthridge J M
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease with highly variable clinical presentation. Patients suffer from immunological abnormalities that target T-cell, B-cell and accessory cell functions. B cells are hyperactive in SLE patients. An adapter protein expressed in B cells called BANK1 (B-cell scaffold protein with ankyrin repeats) was reported in a previous study to be associated with SLE in a...
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