Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis.

doi:10.1371/journal.pone.0061044

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Article

Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis.

PloS one - 1 Jan 2013

Génin Emmanuelle, Coustet Baptiste, Allanore Yannick, Ito Ikue, Teruel Maria, Constantin Arnaud, Schaeverbeke Thierry, Ruyssen-Witrand Adeline, Tohma Shigeto, Cantagrel Alain, Vittecoq Olivier, Barnetche Thomas, Le Loët Xavier, Fardellone Patrice, Furukawa Hiroshi, Meyer Olivier, Fernández-Gutiérrez Benjamin, Balsa Alejandro, González-Gay Miguel A, Chiocchia Gilles, Tsuchiya Naoyuki, Martin Javier, Dieudé Philippe

Abstract excerpt

BACKGROUND: BANK1 and BLK belong to the pleiotropic autoimmune genes; recently, epistasis between BANK1 and BLK was detected in systemic lupus erythematosus. Although BLK has been reproducibly identified as a risk factor in rheumatoid arthritis (RA), reports are conflicting about the contribution of BANK1 to RA susceptibility. To ascertain the real impact of BANK1 on RA genetic susceptibility, we performed a...

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PMID: 23646104
DOI: 10.1371/journal.pone.0061044
PMCID: PMC3639995

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