Article
Short communication: lack of correlation between UGT1A1*6, *28 genotypes, and plasma raltegravir concentrations in Japanese HIV type 1-infected patients.
AIDS research and human retroviruses - 1 Aug 2012
Hirano Atsushi, Ikemura Kenji, Takahashi Masaaki, Shibata Masaaki, Amioka Katsuo, Nomura Toshiharu, Yokomaku Yoshiyuki, Sugiura Wataru
Abstract excerpt
Raltegravir is metabolized by glucuronidation via UDP-glucuronosyltransferase 1A1 (UGT1A1). We analyzed the genotypes of UGT1A1 (*6, *27, and *28) and their contribution to plasma raltegravir concentrations in 56 Japanese HIV-1-infected patients in the National Hospital Organization Nagoya Medical Center of Japan. Among the 56 patients, the UGT1A1 genotype in two patients was *6 homozygote. Heterozygous variants...
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