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Short communication: UGT1A1*28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil.

AIDS research and human retroviruses - 1 Sept 2012

Turatti Lisiane, Sprinz Eduardo, Lazzaretti Rosmeri K, Kuhmmer Regina, Agnes Grasiela, Silveira Jussara M, Basso Rossana P, Pinheiro Cezar A T, Silveira Mariângela F, de Almeida Silvana, Ribeiro Jorge P, Mattevi Vanessa S

Abstract excerpt

Highly active antiretroviral therapy (HAART) has increased the survival of HIV-infected patients. However, adverse effects play a major role in adherence to HAART. Some protease inhibitors (mainly atazanavir and indinavir) act as inhibitors of uridine diphosphate-glucuronosyltransferase (UGT1A1), the enzyme responsible for hepatic conjugation of bilirubin. Variations in the promoter region of the UGT1A1 gene...

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Identifiers

PMID: 22050734
DOI: 10.1089/AID.2011.0261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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