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Article

Impact of UGT1A1 gene polymorphisms on plasma dolutegravir trough concentrations and neuropsychiatric adverse events in Japanese individuals infected with HIV-1.

BMC infectious diseases - 16 Sept 2017

Yagura Hiroki, Watanabe Dai, Kushida Hiroyuki, Tomishima Kosuke, Togami Hiroaki, Hirano Atsushi, Takahashi Masaaki, Hirota Kazuyuki, Ikuma Motoko, Kasai Daisuke, Nishida Yasuharu, Yoshino Munehiro, Yamazaki Kunio, Uehira Tomoko, Shirasaka Takuma

Abstract excerpt

BACKGROUND: Dolutegravir (DTG) is metabolized mainly by uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1), and partly by cytochrome P450 3A (CYP3A). Therefore, we focused on UGT1A1 gene polymorphisms (*6 and *28) in Japanese individuals infected with human immunodeficiency virus (HIV...

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Identifiers

PMID: 28915895
DOI: 10.1186/s12879-017-2717-x
PMCID: PMC5603066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-28915895-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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