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Article

CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema.

Clinical science (London, England : 1979) - 1 Mar 2012

Mishra Aastha, Ali Zahara, Vibhuti Arpana, Kumar Rahul, Alam Perwez, Ram Rekhbala, Thinlas Tashi, Mohammad Ghulam, Pasha M A Qadar

Abstract excerpt

HAPE (high-altitude pulmonary oedema) is characterized by pulmonary hypertension, vasoconstriction and an imbalance in oxygen-sensing redox switches. Excess ROS (reactive oxygen species) contribute to endothelial damage under hypobaric hypoxia, hence the oxidative-stress-related genes CYBA (cytochrome b-245 α polypeptide) and GSTP1 (glutathione transferase Pi 1) are potential candidate genes for HAPE. In the...

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Source

Identifiers

PMID: 21973220
DOI: 10.1042/CS20110205

Genes

CYBA
GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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