Article
Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters.
Clinica chimica acta; international journal of clinical chemistry - 1 Jul 2009
Qi Yue, Niu Wen-Quan, Zhu Tong-Chun, Liu Jing-Liang, Dong Wei-Ya, Xu Ying, Ding Shou-Quan, Cui Cheng-Bing, Pan Yun-Jun, Yu Guo-Shu, Zhou Wen-Yu, Qiu Chang-Chun
Abstract excerpt
BACKGROUND: High-altitude pulmonary edema (HAPE) is thought of as an independent clinical disorder with a constitutional or genetic component in its etiology. We focused on 5 common polymorphisms within HSPA1A (rs1043618 and rs1008438), HSPA1B (rs1061581 and rs539689) and HSPA1L (rs2227956) of Hsp70 family to explore their potential interaction upon susceptibility to HAPE in Chinese. METHODS: A total of 148 HAPE...