Article
Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family.
Blood cells, molecules & diseases - 1 Jan 2000
Lorenzo V Felipe, Yang Yingzhong, Simonson Tatum S, Nussenzveig Roberto, Jorde Lynn B, Prchal Josef T, Ge Ri-Li
Abstract excerpt
Organismal response to hypoxia is essential for critical regulation of erythropoiesis, other physiological functions, and survival. There is evidence of individual variation in response to hypoxia as some but not all of the affected individuals develop polycythemia, and or pulmonary and cerebral edema. A significant population difference in response to hypoxia exist as many highland Tibetan, Ethiopian, and Andean...
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