Article
Study of mutational specificity in the lacl gene of Escherichia coli as a window on the mechanisms of mutation.
Environmental and molecular mutagenesis - 1 Jan 1990
Glickman B W
Abstract excerpt
Whereas in the past we had to be content with mutation induction and survival curves, the recently developed technologies permitting the rapid cloning and sequencing of mutant alleles have provided a new window through which to examine the nature of mutation. These technologies make it possible to determine the precise nature of the mutational alteration as well as the local DNA context. This information has...
Topics
- Alkylating Agents
- Base Sequence
- DNA Repair
- DNA, Bacterial
- Escherichia coli
- Genes, Bacterial
- Lac Operon
- Mutagenicity Tests
- Mutation
- Repressor Proteins