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Article

X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012

Han Li, Mao Weifeng, Yu Kefei

Abstract excerpt

DNA double-strand breaks (DSBs) are essential intermediates in Ig gene rearrangements: V(D)J and class switch recombination (CSR). In contrast to V(D)J recombination, which is almost exclusively dependent on nonhomologous end joining (NHEJ), CSR can occur in NHEJ-deficient cells via a poorly understand backup pathway (or pathways) often termed alternative end joining (A-EJ). Recently, several components of the...

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Source

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Identifiers

PMID: 22392994
DOI: 10.1073/pnas.1120743109
PMCID: PMC3311337

Genes

XRCC1
SSB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining.PMID 22392994Read ↗

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in <i>Igh</i> genesSemantic proximity Read ↗

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Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70Semantic proximity Read ↗

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53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ.Semantic proximity Read ↗

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell lineSemantic proximity Read ↗

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