Article
4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron.
Chemical research in toxicology - 21 Nov 2011
Baradat Maryse, Jouanin Isabelle, Dalleau Sabine, Taché Sylviane, Gieules Mathilde, Debrauwer Laurent, Canlet Cécile, Huc Laurence, Dupuy Jacques, Pierre Fabrice H F, Guéraud Françoise
Abstract excerpt
Animal and epidemiological studies suggest that dietary heme iron would promote colorectal cancer. Oxidative properties of heme could lead to the formation of cytotoxic and genotoxic secondary lipid oxidation products, such as 4-hydroxy-2(E)-nonenal (HNE). This compound is more cytotoxic to mouse wild-type colon cells than to isogenic cells with a mutation on the adenomatous polyposis coli (APC) gene. The latter...
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