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DNA-repair genes and vitamin E in the prevention of N-nitrosodiethylamine mutagenicity.

Cell biology and toxicology - 1 Aug 2009

Aiub Claudia Alessandra Fortes, Pinto Luis Felipe Ribeiro, Felzenszwalb Israel

Abstract excerpt

Nitrosamines are stable compounds, biologically and chemically inert unless activated. In biological systems, N-nitrosodiethylamine (NDEA) can be activated by a variety of enzymes, leading to aldehydes and/or intermediates which are themselves alkylating agents. Additionally, it has been shown that NDEA causes reactive oxygen species (ROS) production and induces mutagenicity. The cell defense seeks to neutralize...

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Identifiers

PMID: 18581242
DOI: 10.1007/s10565-008-9093-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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