Article

Ethanol-induced formation of colorectal tumours and precursors in a mouse model of Lynch syndrome

2021-01-01

Abstract excerpt

Lynch Syndrome (LS) confers an inherited cancer predisposition, particularly for colorectal cancer, due to germline mutations in one of the DNA mismatch repair (MMR) genes, such as MSH2. MMR is a DNA damage repair pathway involved in the removal of base mismatches and insertion/deletion loops, caused by several endogenous and exogenous factors. Loss of MMR through somatic alteration of the wild-type MMR allele in...

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Literature Corpus work: 1e12da58-46ba-54c2-9542-c6fa0383b4dc
DOI: 10.7488/era/1235

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