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Hemin, a major heme molecule, induced cellular and genetic alterations in normal colonic and colon cancer cells.

Pathology, research and practice - 1 Aug 2021

Kodagoda Gamage Sujani Madhurika, Cheng Tracie, Lee Katherine Ting-Wei, Dissabandara Lakal, Lam Alfred King-Yin, Gopalan Vinod

Abstract excerpt

Heme, a molecule abundant in red meat, is assumed to exert carcinogenic effects on normal colonic cells and tumour suppressive effects on cancer cells, though the hypothesis has not been explicitly proven yet. The present study aims to investigate hemin induced cytotoxic, genetic and biological alterations in both normal and cancerous colonic epithelial cells, which may imply its carcinogenic and anticarcinogenic...

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Carcinogenesis
Carcinogens
Colon
Colonic Neoplasms
Epithelial Cells

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PMID: 34243108
DOI: 10.1016/j.prp.2021.153530

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