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Article

Progress in the genetics of ankylosing spondylitis

1 Sept 2011

Abstract excerpt

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthropathy. In addition to being strongly associated with HLA-B27, a further 13 genes have been robustly associated with the disease. These genes highlight the involvement of the IL-23 pathway in disease pathogenesis, and indicate overlaps between the pathogenesis of AS, and of inflammatory bowel disease. Genetic associations in B27-positive...

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PMID: 21965815
DOI: 10.1093/bfgp/elr023

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