Article
The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease.
Rheumatology international - 1 Dec 2022
Kenyon Marcus, Maguire Sinead, Rueda Pujol Anna, O'Shea Finbar, McManus Ross
Abstract excerpt
Ankylosing spondylitis (AS) is a seronegative, chronic inflammatory arthritis with high genetic burden. A strong association with HLA-B27 has long been established, but to date its contribution to disease aetiology remains unresolved. Recent insights through genome wide studies reveal an increasing array of immunogenetic risk variants extraneous to the HLA complex in AS cohorts. These genetic traits build a...
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