Article
Genetics and genomics of ankylosing spondylitis.
Immunological reviews - 1 Jan 2010
Thomas Gethin P, Brown Matthew A
Abstract excerpt
Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of which is poorly understood. The mechanism by which the main gene for the disease, HLA-B27, leads to AS is unknown. Genetic and genomic studies have demonstrated involvement of the interleukin-23 (IL-23) signaling pathway in AS, a finding which has stimulated much new research into the disease and has led to therapeutic...
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