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Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects.

Molecular genetics and metabolism - 1 Dec 2011

Mohammedi Kamel, Maimaitiming Suliya, Emery Nathalie, Bellili-Muñoz Naima, Roussel Ronan, Fumeron Frédéric, Hadjadj Samy, Marre Michel, Velho Gilberto

Abstract excerpt

BACKGROUND: Oxidative stress is involved in the pathophysiology of diabetic nephropathy. The superoxide dismutase (SOD) enzymes play a major role in detoxification of reactive oxygen species and have a protective effect against diabetic nephropathy. We investigated associations of allelic variations in SOD1 gene with nephropathy in patients with type 1 diabetes. METHODS: Seven SNPs in SOD1 region were analyzed in...

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Cross-Sectional Studies
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Glomerular Filtration Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proportional Hazards Models

Superoxide Dismutase

Superoxide Dismutase-1

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PMID: 21963083
DOI: 10.1016/j.ymgme.2011.08.033

Genes

SOD1

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