Article
Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study.
Diabetes - 1 Jan 2008
Al-Kateb Hussam, Boright Andrew P, Mirea Lucia, Xie Xinlei, Sutradhar Rinku, Mowjoodi Alireza, Bharaj Bhupinder, Liu Michelle, Bucksa Jean M, Arends Valerie L, Steffes Michael W, Cleary Patricia A, Sun Wanjie, Lachin John M, Thorner Paul S, Ho Michael, McKnight Amy Jayne, Maxwell A Peter, Savage David A, Kidd Kenneth K, Kidd Judith R, Speed William C, Orchard Trevor J, Miller Rachel G, Sun Lei, Bull Shelley B, Paterson Andrew D
Abstract excerpt
BACKGROUND: Despite familial clustering of nephropathy and retinopathy severity in type 1 diabetes, few gene variants have been consistently associated with these outcomes. RESEARCH DESIGN AND METHODS: We performed an individual-based genetic association study with time to renal and retinal outcomes in 1,362 white probands with type 1 diabetes from the Diabetes Control and Complications Trial/Epidemiology of...
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