Article
Allelic variations in superoxide dismutase-1 (SOD1) gene and renal and cardiovascular morbidity and mortality in type 2 diabetic subjects.
Molecular genetics and metabolism - 1 Jul 2012
Neves Ana Luísa, Mohammedi Kamel, Emery Nathalie, Roussel Ronan, Fumeron Frédéric, Marre Michel, Velho Gilberto
Abstract excerpt
BACKGROUND: Oxidative stress is involved in the pathophysiology of renal and cardiovascular complications of diabetes. Superoxide dismutase (SOD) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. Associations of SOD1 gene variants with diabetic nephropathy were reported in patients with type 1 diabetes. We investigated associations of allelic...
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