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Polymorphic differences in the SOD-2 gene may affect the pathogenesis of nephropathy in patients with diabetes and diabetic complications.

Gene - 10 Sept 2015

Houldsworth Annwyne, Hodgkinson Andrea, Shaw Steve, Millward Ann, Demaine Andy G

Abstract excerpt

UNLABELLED: The effective treatment of diabetes and the prevention of diabetic complications may be improved by a better understanding of the antioxidant function of intracellular defences against oxidative stress. Polymorphisms in antioxidant genes may determine cellular oxidative stress levels as a primary pathogenic role in diabetes and/or in its complications. SOD-2 was investigated in patients with type 1...

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Antioxidants
Diabetes Complications
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Association Studies

Oxidative Stress

Superoxide Dismutase

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PMID: 25858271
DOI: 10.1016/j.gene.2015.04.006

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