Article
Association of single nucleotide polymorphisms in the gene encoding GLUT1 and diabetic nephropathy in Brazilian patients with type 1 diabetes mellitus.
Clinica chimica acta; international journal of clinical chemistry - 15 Apr 2015
Marques T, Patente T A, Monteiro M B, Cavaleiro A M, Queiroz M S, Nery M, de Azevedo M J, Canani L H, Parisi M C, Moura-Neto A, Passarelli M, Giannella-Neto D, Machado U F, Corrêa-Giannella M L
Abstract excerpt
Mesangial cells subject to high extracellular glucose concentrations, as occur in hyperglycaemic states, are unable to down regulate glucose influx, resulting in intracellular activation of deleterious biochemical pathways. A high expression of GLUT1 participates in the development of diabetic glomerulopathy. Variants in the gene encoding GLUT1 (SLC2A1) have been associated to this diabetic complication. The aim...
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