Article
Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant.
Biochemistry - 1 Nov 2011
Liu Min, Kang Stephanie, Ray Soumya, Jackson Justin, Zaitsev Alexandra D, Gerber Scott A, Cuny Gregory D, Glicksman Marcie A
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson's disease (PD). Here, we characterize the kinetic and catalytic mechanisms of truncated wild-type (t-wt) LRRK2 and its most common mutant, G2019S (t-G2019S), with a structural interpretation of the kinase domain. First, the substitution of...
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