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Article

MicroRNA profiles of t(14;18)-negative follicular lymphoma support a late germinal center B-cell phenotype.

Blood - 17 Nov 2011

Leich Ellen, Zamo Alberto, Horn Heike, Haralambieva Eugenia, Puppe Bernhard, Gascoyne Randy D, Chan Wing-Chung, Braziel Rita M, Rimsza Lisa M, Weisenburger Dennis D, Delabie Jan, Jaffe Elaine S, Fitzgibbon Jude, Staudt Louis M, Mueller-Hermelink Hans-Konrad, Calaminici Mariarita, Campo Elias, Ott German, Hernández Luis, Rosenwald Andreas

Abstract excerpt

A total of 90% of follicular lymphomas (FLs) harbor the translocation t(14;18) leading to deregulated BCL2 expression. Conversely, 10% of FLs lack the t(14;18), and the majority of these FLs do not express BCL2. The molecular features of t(14;18)-negative FLs remain largely unknown. We performed microRNA expression analysis in 32 FL grades 1 to 3A, including 17 t(14;18)-positive FLs, 9 t(14;18)-negative FLs...

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Share to Checkpoint Kinase 1
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 18

Share to Germinal Center

Share to Lymphoma, B-Cell

Share to Lymphoma, Follicular

Share to Proto-Oncogene Proteins c-bcl-2

Share to Translocation, Genetic

Source

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Identifiers

PMID: 21960592
DOI: 10.1182/blood-2011-06-361972
PMCID: PMC3217356

Genes

BCL2
CHEK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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