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Article

Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays

1 Jan 2002

Abstract excerpt

Follicular lymphomas (FLs) are neoplastic counterparts of normal germinal center (GC) B cells. FLs are characterized by t(14;18) with deregulation of the Bcl-2 (BCL2) gene. The presence of t(14;18) and overexpression of Bcl-2 is necessary, but not sufficient, to cause this disease. An array containing 588 complementary DNAs (cDNAs) was used to compare the gene expression between GC B cells and FL cells. To...

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PMID: 11756183
DOI: 10.1182/blood.v99.1.282

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