Article
CREBBP and STAT6 co-mutation and 16p13 and 1p36 loss define the t(14;18)-negative diffuse variant of follicular lymphoma.
Blood cancer journal - 17 Jun 2020
Xian Rena R, Xie Yi, Haley Lisa M, Yonescu Raluca, Pallavajjala Aparna, Pittaluga Stefania, Jaffe Elaine S, Duffield Amy S, McCall Chad M, Gheith Shereen M F, Gocke Christopher D
Abstract excerpt
The diffuse variant of follicular lymphoma (dFL) is a rare variant of FL lacking t(14;18) that was first described in 2009. In this study, we use a comprehensive approach to define unifying pathologic and genetic features through gold-standard pathologic review, FISH, SNP-microarray, and next-generation sequencing of 16 cases of dFL. We found unique morphologic features, including interstitial sclerosis,...
Topics
- Adult
- Aged
- CREB-Binding Protein
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 16
- Female
- Humans
- Lymphoma, Follicular
- Male