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FGFR2 maintains cancer cell differentiation via AKT signaling in esophageal squamous cell carcinoma

3 Jun 2021

Abstract excerpt

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are important for signaling to maintain cancer stem-like cells (CSCs) in esophageal squamous cell carcinoma (ESCC). However, which FGF receptor, 1, 2, 3, 4, and L1, is essential or whether FGFRs have distinct different roles in ESCC-CSCs is still in question. This study shows that FGFR2, particularly the IIIb isoform, is highly expressed in non-CSCs....

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PMID: 34224333
DOI: 10.1080/15384047.2021.1939638

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