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Article

Role of PKCε in the epithelial-mesenchymal transition induced by FGFR2 isoform switch

19 May 2020

Abstract excerpt

BACKGROUND: The epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) controls the entire program of keratinocyte differentiation via the sequential involvement of protein kinase C (PKC) δ and PKCα. In contrast, the FGFR2 isoform switch and the aberrant expression of the mesenchymal FGFR2c isoform leads to impairment of differentiation, epithelial-mesenchymal transition (EMT) and tumorigenic...

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PMID: 32429937
DOI: 10.1186/s12964-020-00582-1

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