Article
A new minimal deleted region at 11q22.3 reveals the importance of interpretation of diminished FISH signals and the choice of probe for ATM deletion screening in chronic lymphocytic leukemia.
Leukemia research - 1 Mar 2012
Gardiner Anne, Parker Helen, Glide Sharron, Mould Sarah, Robinson Hazel, Tracy Ian, Stankovic Tanja, Oscier David, Strefford Jon
Abstract excerpt
Deletion of ATM detected by fluorescent in situ hybridization (FISH) in chronic lymphocytic leukemia predicts short treatment free survival and poor outcome following alkylator/purine analogue therapy. We describe five cases, with a diminished ATM FISH signal, investigated by TP53 mutation/dysfunction studies and single nucleotide polymorphism (SNP) array. The diminished signal represented loss of the ATM gene,...
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