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Molecular characterization of Novel ATM fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia.

Leukemia & lymphoma - 1 Apr 2022

Kanagal-Shamanna Rashmi, Bao Haiyan, Kearney Hutton, Smoley Stephanie, Tang Zhenya, Luthra Rajyalakshmi, Yang Hui, Zhang Shanshan, Lin Pei, Wu Depei, Medeiros L Jeffrey, Lu Xinyan

Abstract excerpt

ATM deletions and/or mutations are recurrent in lymphoid neoplasms while rearrangements are rare. In this study, we used mate pair sequencing (MPseq) technology to characterize two novel ATM rearrangements in one patient with chronic lymphocytic leukemia (CLL) and one patient with T-prolymphocytic leukemia (T-PLL). Both patients showed chromosome 11q22 aberrations encompassing ATM by conventional karyotype and...

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PMID: 34898335
DOI: 10.1080/10428194.2021.2010061

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