Article
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.
Haematologica - 1 Apr 2014
Rose-Zerilli Matthew J J, Forster Jade, Parker Helen, Parker Anton, Rodríguez Ana E, Chaplin Tracy, Gardiner Anne, Steele Andrew J, Collins Andrew, Young Bryan D, Skowronska Anna, Catovsky Daniel, Stankovic Tatjana, Oscier David G, Strefford Jonathan C
Abstract excerpt
ATM mutation and BIRC3 deletion and/or mutation have independently been shown to have prognostic significance in chronic lymphocytic leukemia. However, the relative clinical importance of these abnormalities in patients with a deletion of 11q encompassing the ATM gene has not been established. We screened a cohort of 166 patients enriched for 11q-deletions for ATM mutations and BIRC3 deletion and mutation and...
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