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EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartment

28 Sept 2011

Abstract excerpt

PURPOSE: There are conflicting reports regarding the function of EFEMP1 in different cancer types. In this study, we sought to evaluate the role of EFEMP1 in malignant glioma biology. EXPERIMENTAL DESIGN: Real-time qRT-PCR was used to quantify EFEMP1 expression in 95 glioblastoma multiforme (GBM). Human high-grade glioma cell lines and primary cultures were engineered to express ectopic EFEMP1, a small hairpin...

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PMID: 21955618
DOI: 10.1186/1476-4598-10-123

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