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Article

EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastoma

7 Dec 2013

Abstract excerpt

// Lotte Hiddingh 1,2,3 , Bakhos A. Tannous 4 , Jian Teng 4 , Bas Tops 5 , Judith Jeuken 5,7 , Esther Hulleman 2,3 , Sandra H. Boots-Sprenger 5 , W. Peter Vandertop 1 , David P. Noske 1,3 , Gertjan J.L. Kaspers 2 , Pieter Wesseling 5,6 , Thomas Wurdinger 1,3,4 1 Department of Neurosurgery, VU University Medical Center, Amsterdam, The Netherlands 2 Department of Pediatric Oncology, VU University Medical Center,...

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PMID: 24495907
DOI: 10.18632/oncotarget.1620

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EFEMP1 induces γ-secretase/Notch-mediated temozolomide resistance in glioblastomaPMID 24495907Read ↗

EFEMP1 suppresses malignant glioma growth and exerts its action within the tumor extracellular compartmentSemantic proximity Read ↗

Induction Of XLF And 53BP1 Expression Is Associated With Temozolomide Resistance In Glioblastoma CellsSemantic proximity Read ↗

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumorsSemantic proximity Read ↗

Inhibition of Wnt/beta-catenin signaling downregulates expression of aldehyde dehydrogenase isoform 3A1 (ALDH3A1) to reduce resistance against temozolomide in glioblastoma in vitroSemantic proximity Read ↗

YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell lineSemantic proximity Read ↗

The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic ResistanceSemantic proximity Read ↗

A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating CellsSemantic proximity Read ↗

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Silencing of MEG3 gene promoted anti-cancer activity and drug sensitivity in gliomaSemantic proximity Read ↗

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