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Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of <i>DKK1</i> correlates with clinical bone involvement at diagnosis

14 Nov 2007

Abstract excerpt

Osteolytic bone disease (OBD) in multiple myeloma (MM) is caused by interactions between MM cells and the bone marrow microenvironment and is characterized by increased osteoclastic bone resorption and decreased osteoblastic bone formation. Recently, the role of osteoblast inhibition has come into focus, especially the possible role of overexpression of DKK1, an inhibitor of the Wnt signalling pathway. Further,...

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PMID: 18005268
DOI: 10.1111/j.1365-2141.2007.06871.x

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