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Article

Factors affecting the role of canonical Wnt inhibitor Dickkopf-1 in cancer progression

15 Mar 2023

Abstract excerpt

Background: The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has the capacity to modulate homeostasis between canonical and non-canonical Wnt pathways and also signal independently of Wnt. The specific effects of Dkk-1 activity on tumor physiology are therefore unpredictable with examples of Dkk-1 serving as either a driver or suppressor of malignancy. Given that Dkk-1 blockade may serve as a potential treatment...

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Identifiers

PMID: 37007131
DOI: 10.3389/fonc.2023.1114822

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