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Article

Identification and characterization of a lupus suppressor 129 locus on chromosome 3.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2010

Carlucci Francesco, Fossati-Jimack Liliane, Dumitriu Ingrid E, Heidari Yasin, Walport Mark J, Szajna Marta, Baruah Paramita, Garden Oliver A, Cook H Terence, Botto Marina

Abstract excerpt

The 129-derived Sle16 is a susceptibility locus for systemic autoimmunity when present on the C57BL/6 (B6) background. Genetic analysis of a (129xB6)F2 cross identified a region from the B6 chromosome 3 (Sle18) with positive linkage to antinuclear Abs. In this study, we have generated a B6 congenic strain harboring the 129 allele of Sle18 and intercrossed this line with the lupus-prone B6.129-Sle16 strain. The...

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Identifiers

PMID: 20435933
DOI: 10.4049/jimmunol.0901463
PMCID: PMC3698755

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and characterization of a lupus suppressor 129 locus on chromosome 3.PMID 20435933Read ↗

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