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Article

Gene variations in oestrogen pathways, CYP19A1, daily 17β-estradiol and mammographic density phenotypes in premenopausal women.

Breast cancer research : BCR - 19 Dec 2014

Flote Vidar G, Furberg Anne-Sofie, McTiernan Anne, Frydenberg Hanne, Ursin Giske, Iversen Anita, Lofteroed Trygve, Ellison Peter T, Wist Erik A, Egeland Thore, Wilsgaard Tom, Makar Karen W, Chang-Claude Jenny, Thune Inger

Abstract excerpt

INTRODUCTION: High mammographic density is an established breast cancer risk factor, and circulating oestrogen influences oestrogen-regulating gene expression in breast cancer development. However, less is known about the interrelationships of common variants in the CYP19A1 gene, daily levels of oestrogens, mammographic density phenotypes and body mass index (BMI) in premenopausal women. METHODS: Based on...

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Identifiers

PMID: 25522654
DOI: 10.1186/s13058-014-0499-2
PMCID: PMC4303212

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