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Article

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.

Science (New York, N.Y.) - 1 Feb 2002

Lando David, Peet Daniel J, Whelan Dean A, Gorman Jeffrey J, Whitelaw Murray L

Abstract excerpt

The hypoxia-inducible factors (HIFs) 1alpha and 2alpha are key mammalian transcription factors that exhibit dramatic increases in both protein stability and intrinsic transcriptional potency during low-oxygen stress. This increased stability is due to the absence of proline hydroxylation, which in normoxia promotes binding of HIF to the von Hippel-Lindau (VHL tumor suppressor) ubiquitin ligase. We now show that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11823643
DOI: 10.1126/science.1068592

Genes

CAD
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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