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Article

Insights into hemoglobin assembly through in vivo mutagenesis of α-hemoglobin stabilizing protein.

The Journal of biological chemistry - 30 Mar 2012

Khandros Eugene, Mollan Todd L, Yu Xiang, Wang Xiaomei, Yao Yu, D'Souza Janine, Gell David A, Olson John S, Weiss Mitchell J

Abstract excerpt

α-Hemoglobin stabilizing protein (AHSP) is believed to facilitate adult Hemoglobin A assembly and protect against toxic free α-globin subunits. Recombinant AHSP binds multiple forms of free α-globin to stabilize their structures and inhibit precipitation. However, AHSP also stimulates autooxidation of αO(2) subunit and its rapid conversion to a partially unfolded bishistidyl hemichrome structure. To investigate...

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Source

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Identifiers

PMID: 22287545
DOI: 10.1074/jbc.M111.313205
PMCID: PMC3322894

Genes

AHSP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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