Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

α-Haemoglobin stabilising protein expression is influenced by mean cell haemoglobin and HbF levels in HbE/β-thalassaemia individuals.

Blood cells, molecules & diseases - 15 Jan 2012

Lim Wai Feng, Muniandi Logeswaran, George Elizabeth, Sathar Jameela, Teh Lai Kuan, Gan Gin Gin, Lai Mei I

Abstract excerpt

The alpha haemoglobin stabilising protein (AHSP) acts as a molecular chaperone for α-globin by stabilising nascent α-globin before transferring it to waiting free β-globin chains. Binding of AHSP to α-globin renders α-globin chemically inert whereby preventing it from precipitating and forming reactive oxygen species byproducts. The AHSP has been actively studied in the recent years, particularly in its relation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Globins
Share to beta-Globins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to beta-Thalassemia

Share to Blood Proteins

Share to Erythrocyte Indices

Share to Fetal Hemoglobin

Share to gamma-Globins

Share to Hemoglobin E

Source

Identifiers

PMID: 22079025
DOI: 10.1016/j.bcmd.2011.10.002

Genes

AHSP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

α-Haemoglobin stabilising protein expression is influenced by mean cell haemoglobin and HbF levels in HbE/β-thalassaemia individuals.PMID 22079025Read ↗

Alpha hemoglobin stabilizing protein: Its causal relationship with the severity of beta thalassemia.Semantic proximity Read ↗

Role of alpha-hemoglobin-stabilizing protein in normal erythropoiesis and beta-thalassemia.Semantic proximity Read ↗

Impact of α-Globin Gene Expression and α-Globin Modifiers on the Phenotype of β-Thalassemia and Other Hemoglobinopathies: Implications for Patient Management.Semantic proximity Read ↗

Loss of α-hemoglobin–stabilizing protein impairs erythropoiesis and exacerbates β-thalassemiaSemantic proximity Read ↗

A twins heritability study on alpha hemoglobin stabilizing protein (AHSP) expression variability.Semantic proximity Read ↗

A molecular study on the role of alpha-hemoglobin-stabilizing protein in hemoglobin H disease.Semantic proximity Read ↗

Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.Semantic proximity Read ↗

An erythroid chaperone that facilitates folding of alpha-globin subunits for hemoglobin synthesis.Semantic proximity Read ↗

α-Hemoglobin stabilizing protein: a modulating factor in thalassemias?Semantic proximity Read ↗

Evaluation of the free α-hemoglobin pool in red blood cells: a new test providing a scale of β-thalassemia severity.Semantic proximity Read ↗

Population analysis of the alpha hemoglobin stabilizing protein (AHSP) gene identifies sequence variants that alter expression and function.Semantic proximity Read ↗

Unstable Alpha Hemoglobin Stabilizing Protein as a Cause of Thalassemia: Proof of Concept.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.