Article

Unstable Alpha Hemoglobin Stabilizing Protein as a Cause of Thalassemia: Proof of Concept.

2009-11-20

Abstract excerpt

Abstract Abstract 462 Alpha hemoglobin stabilizing protein (AHSP), a small 102-residue protein previously known as erythroid differentiation-related factor (EDRF), is present only in erythroid cells, where it acts as a chaperone of α-Hb by forming a stable complex which prevents the aggregation of excess α-Hb that by precipitation would damage membrane structure and trigger cell death. AHSP knock-out mice exhibit...

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Literature Corpus work: 5c368f4d-c549-5623-b506-6e2cbe593c09
DOI: 10.1182/blood.v114.22.462.462

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