Article
Evaluation of intra-host variants of the entire hepatitis B virus genome.
PloS one - 1 Jan 2011
Ramachandran Sumathi, Zhai Xiangjun, Thai Hong, Campo Davis S, Xia Guoliang, Ganova-Raeva Lilia M, Drobeniuc Jan, Khudyakov Yury E
Abstract excerpt
Genetic analysis of hepatitis B virus (HBV) frequently involves study of intra-host variants, identification of which is commonly achieved using short regions of the HBV genome. However, the use of short sequences significantly limits evaluation of genetic relatedness among HBV strains. Although analysis of HBV complete genomes using genetic cloning has been developed, its application is highly labor intensive...
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