Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes

23 Sept 2011

Abstract excerpt

Many human diseases share a developmental origin that manifests during childhood or maturity. Aneuploid syndromes are caused by supernumerary or reduced number of chromosomes and represent an extreme example of developmental disease, as they have devastating consequences before and after birth. Investigating how alterations in gene dosage drive these conditions is relevant because it might help treat some...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21949351
DOI: 10.1093/hmg/ddr435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromesPMID 21949351Read ↗

Human Embryonic Stem Cells as Models for Aneuploid Chromosomal SyndromesSemantic proximity Read ↗

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells.Semantic proximity Read ↗

An iPSC-based model of Jacob Syndrome reveals a DNA methylation-independent transcriptional dysregulation shared with X aneuploid cellsSemantic proximity Read ↗

Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest networkSemantic proximity Read ↗

Generation of human induced pluripotent stem cells from a patient with Beckwith-Wiedemann syndromeSemantic proximity Read ↗

Monosomy X in isogenic human iPSC-derived trophoblast model impacts expression modules preserved in human placentaSemantic proximity Read ↗

Derivation and investigation of the first human cell-based model of Beckwith-Wiedemann syndrome.Semantic proximity Read ↗

Perspectives for induced pluripotent stem cell technology: new insights into human physiology involved in somatic mosaicism.Semantic proximity Read ↗

Preimplantation genetic diagnosis as a source of human embryonic stem cells for disease research and drug discoverySemantic proximity Read ↗

Generation of the human induced pluripotent stem cell line PUMCi005-A from a patient with Perrault syndrome.Semantic proximity Read ↗

The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem CellsSemantic proximity Read ↗

Generation of isogenic models of Angelman syndrome and Prader-Willi syndrome in CRISPR/Cas9-engineered human embryonic stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.