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Human Embryonic Stem Cells as Models for Aneuploid Chromosomal Syndromes

16 Jul 2010

Abstract excerpt

Syndromes caused by chromosomal aneuploidies are widely recognized genetic disorders in humans and often lead to spontaneous miscarriage. Preimplantation genetic screening is used to detect chromosomal aneuploidies in early embryos. Our aim was to derive aneuploid human embryonic stem cell (hESC) lines that may serve as models for human syndromes caused by aneuploidies. We have established 25 hESC lines from...

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PMID: 20641042
DOI: 10.1002/stem.483

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