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Article

Preimplantation genetic diagnosis as a source of human embryonic stem cells for disease research and drug discovery

12 Dec 2008

Abstract excerpt

Embryos surplus to therapeutic requirements following preimplantation genetic diagnosis can be used to derive human embryonic stem cell (hESC) lines carrying mutations significant to human disease. These cells provide a powerful in vitro tool for modelling disease progression in a number of cell types as well as having the potential to revolutionise drug discovery. Robust and reproducible directed differentiation...

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PMID: 19076947
DOI: 10.1111/j.1471-0528.2008.02009.x

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