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Article

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells.

Nature medicine - 1 Dec 2011

Tiscornia Gustavo, Vivas Erica Lorenzo, Izpisúa Belmonte Juan Carlos

Abstract excerpt

The derivation of induced pluripotent cells (iPSCs) from individuals suffering from genetic syndromes offers new opportunities for basic research into these diseases and the development of therapeutic compounds. iPSCs can self renew and can be differentiated to many cell types, offering a potentially unlimited source of material for study. In this review we discuss the conceptual and practical issues to consider...

Topics

Animals
Cell Differentiation
Disease Models, Animal
Genetic Diseases, Inborn
Genome, Human
Humans
Induced Pluripotent Stem Cells
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22146428
DOI: 10.1038/nm.2504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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