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Article

Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice

26 Feb 2017

Abstract excerpt

Obesity causes insulin resistance, and PPARγ ligands such as rosiglitazone are insulin sensitizing, yet the mechanisms remain unclear. In C57BL/6 (B6) mice, obesity induced by a high-fat diet (HFD) has major effects on visceral epididymal adipose tissue (eWAT). Here, we report that HFD-induced obesity in B6 mice also altered the activity of gene regulatory elements and genome-wide occupancy of PPARγ....

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PMID: 28240605
DOI: 10.1172/jci91211

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