Article
Tuning of antibacterial activity of a cyclopropyl fluoroquinolone by variation of the substituent at position C-8.
The Journal of antimicrobial chemotherapy - 1 Dec 2011
Wetzstein H-G, Hallenbach W
Abstract excerpt
OBJECTIVES: If substituted at position C-8 by a methoxy group, fluoroquinolones possess antibacterial efficacy considerably improved over that of C-H analogues. The new veterinary fluoroquinolone pradofloxacin bears a cyano group at C-8 and it was attempted to define the ranges of activity unfolding upon variation of this moiety. METHODS: Pradofloxacin and six analogues were subjected to MIC and mutant prevention...
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