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Article

Fluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistance.

Antimicrobial agents and chemotherapy - 1 Nov 1998

Dong Y, Xu C, Zhao X, Domagala J, Drlica K

Abstract excerpt

Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In the present study, a C-8-methoxyl group improved bacteriostatic action against gyrA (gyrase-resistant) strains of Mycobacterium tuberculosis and M. bovis BCG. It also enhanced lethal...

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Identifiers

PMID: 9797236
DOI: 10.1128/AAC.42.11.2978
PMCID: PMC105976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Fluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistance.PMID 9797236Read ↗

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