Article
Fluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistance.
Antimicrobial agents and chemotherapy - 1 Nov 1998
Dong Y, Xu C, Zhao X, Domagala J, Drlica K
Abstract excerpt
Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In the present study, a C-8-methoxyl group improved bacteriostatic...
Topics
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Fluoroquinolones
- Mutation
- Mycobacterium
- Structure-Activity Relationship