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Article

Comparative mutant prevention concentration and mechanism of resistance to veterinary fluoroquinolones in Staphylococcus pseudintermedius.

Veterinary dermatology - 1 Aug 2012

Awji Elias Gebru, Tassew Dereje Damte, Lee Joong-Su, Lee Seung-Jin, Choi Myung-Jin, Reza Mohammad Ahsanur, Rhee Man-Hee, Kim Tae-Hwan, Park Seung-Chun

Abstract excerpt

BACKGROUND: The problem of antibacterial drug resistance is increasing worldwide, in part due to the therapeutic concentrations currently used based on the minimal inhibitory concentration (MIC) as a measure of potency are often the very concentrations required to selectively enrich the resistant mutant portion of the population. A mutant prevention concentration (MPC)-based dosing strategy is suggested to...

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PMID: 22409306
DOI: 10.1111/j.1365-3164.2012.01038.x

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